A store - operated Ca 2 + influx pathway in the bag cell neurons of Aplysia by :
نویسندگان
چکیده
Babak A. Kachoei, Ronald J. Knox, Didier Uthuza, Simon Levy, Leonard K. Kaczmarek, and Neil S. Magoski 1 Department of Physiology, Queen’s University, Kingston, ON, K7L 3N6, Canada; and Department of Pharmacology, Yale University, New Haven, CT, 06520, USA; and Department of Physiology and Biophysics, Boston University, Boston, MA, 02118, USA present address: Department of Lead Discovery & Profiling, Bristol Myers-Squibb, 5 Research Parkway, Wallingford, CT, 06492, USA
منابع مشابه
A Store-Operated Ca Influx Pathway in the Bag Cell Neurons of Aplysia
Kachoei, Babak A., Ronald J. Knox, Didier Uthuza, Simon Levy, Leonard K. Kaczmarek, and Neil S. Magoski. A store-operated Ca influx pathway in the bag cell neurons of Aplysia. J Neurophysiol 96: 2688–2698, 2006. First published August 2, 2006; doi:10.1152/jn.00118.2006. Although store-operated Ca influx has been well-studied in nonneuronal cells, an understanding of its nature in neurons remain...
متن کاملA store-operated Ca(2+) influx pathway in the bag cell neurons of Aplysia.
Although store-operated Ca(2+) influx has been well-studied in nonneuronal cells, an understanding of its nature in neurons remains poor. In the bag cell neurons of Aplysia californica, prior work has suggested that a Ca(2+) entry pathway can be activated by Ca(2+) store depletion. Using fura-based imaging of intracellular Ca(2+) in cultured bag cell neurons, we now characterize this pathway as...
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Although the contribution of Ca 2 buffering systems can vary between neuronal types and cellular compartments, it is unknown whether distinct Ca 2 sources within a neuron have different buffers. As individual Ca 2 sources can have separate functions, we propose that each is handled by unique systems. Using Aplysia californica bag cell neurons, which initiate reproduction through an afterdischar...
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The ability of sodium pyrithione (NaP), an agent that produces delayed neuropathy in some species, to alter neuronal physiology was accessed using ratiometric imaging of cytosolic free Ca(2+) concentration ([Ca(2+)](i)) in fura PE-filled cultured Aplysia bag cell neurons. Bath-application of NaP evoked a [Ca(2+)](i) elevation in both somata and neurites with an EC(50) of approximately 300 nM an...
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